CALL FOR PAPERS Cigarette Smoke-Induced Lung Endothelial and Alveolar Epithelial Injury Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway
نویسندگان
چکیده
Priscilla Henno, Jean-François Boitiaux, Benoit Douvry, Aurélie Cazes, Marilyne Lévy, Philippe Devillier, Christophe Delclaux, and Dominique Israël-Biet Unité Propre de Recherche de l’Enseignement Supérieur EA 4068, UFR Biomédicale des Saints Pères, Paris; Université Pierre et Marie Curie, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Service de Physiologie, Hôpital Saint Antoine, Paris; Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Service d’Anatomopathologie, Hôpital Européen Georges Pompidou, Paris; Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Service de Chirurgie Cardiaque, Hôpital Necker-Enfants Malades, Paris; Université Versailles Saint-Quentin, Hôpital Foch, Suresnes; Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Service de Physiologie, Hôpital Européen Georges Pompidou, Paris; and Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, Service de Pneumologie, Hôpital Européen Georges Pompidou, Paris, France
منابع مشابه
Oxidative Stress, Cell Death, and Other Damage to Alveolar Epithelial Cells Induced by Cigarette Smoke
Cigarette smoking is a major risk factor in the development of various lung diseases, including pulmonary emphysema, pulmonary fibrosis, and lung cancer. The mechanisms of these diseases include alterations in alveolar epithelial cells, which are essential in the maintenance of normal alveolar architecture and function. Following cigarette smoking, alterations in alveolar epithelial cells induc...
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Pulmonary vascular remodeling and dysfunction associated to tobacco smoking might pave the way for the subsequent development of pulmonary hypertension. Its prognosis is dreadful and its underlying mechanisms are so far largely unknown in humans. To assess the potential role of endothelin-1 and its receptors in smokers' pulmonary artery vasoactive properties. Endothelium-dependent vasodilation ...
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Endothelial dysfunction is one of the main consequences of the toxic effects of cigarette smoke on the vascular system. Increasing evidence suggests that the small G-protein Rho-A and its downstream effectors, the Rho-kinases (ROCKs), are involved in systemic endothelial dysfunction induced by cigarette smoke. This study aimed to evaluate the role of the RhoA/ROCKs pathway in pulmonary artery e...
متن کاملIncreased Rho-kinase expression and activity and pulmonary endothelial dysfunction in smokers with normal lung function.
Endothelial dysfunction is one of the main consequences of the toxic effects of cigarette smoke on the vascular system. Increasing evidence suggests that the small G-protein RhoA and its downstream effectors, the Rho-kinases (ROCKs), are involved in systemic endothelial dysfunction induced by cigarette smoke. This study aimed to evaluate the role of the RhoA/ROCKs pathway in pulmonary artery en...
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Rehan VK, Sakurai R, Torday JS. Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung. Am J Physiol Lung Cell Mol Physiol 301: L1–L8, 2011. First published April 8, 2011; doi:10.1152/ajplung.00393.2010.—The underlying mechanisms and effector molecules involved in mediating in utero smoke exposure-induced effects on the developing lung are only beginning to be...
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